Why the study?
Does valsartan act as a potent and selective AT1-receptor antagonist and lower blood pressure in preclinical models?
Population
In vitro models and in vivo models
Comparison
Valsartan vs Losartan in marmoset and rat models…
Design
Preclinical
Follow-up
Up to 24 hours for in vivo blood pressure monitoring
Authors
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Animal data support valsartan selectivity and sustained BP effects; leaves open confirmation in randomized human trials.
Does valsartan act as a potent and selective AT1-receptor antagonist and lower blood pressure in preclinical models?
Valsartan is a potent, orally active, and highly selective nonpeptide antagonist of the angiotensin II AT1-receptor that effectively lowers blood pressure in animal models.
Criscione et al. (1993) studied this question.
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