Key result
Valsartan 80 mg significantly lowered the systolic blood pressure response to angiotensin II challenges compared to placebo, with effects maintained up to 24 hours.
Why the study?
Does valsartan 80 mg reduce the angiotensin II pressor response in healthy normotensive men?
RCT (n=6)
Double-blind
crossover
No
Does valsartan 80 mg reduce the angiotensin II pressor response in healthy normotensive men?
Valsartan 80 mg provides rapid and persistent inhibition of the angiotensin II pressor response for up to 24 hours, with no attenuation after 7 days of multiple dosing.
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Supports once-daily valsartan dosing; confirms sustained AT1 blockade without attenuation over 7 days.
Morgan et al. (1997) conducted an RCT in Healthy normotensive (n=6). Valsartan vs. Placebo was evaluated on Systolic blood pressure response to repeated angiotensin II challenges. Valsartan 80 mg significantly lowered the systolic blood pressure response to angiotensin II challenges compared to placebo, with effects maintained up to 24 hours.
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