Why the study?
Does dyscholesterolemia protect against ischemia-induced ventricular arrhythmias in mouse models?
Does dyscholesterolemia protect against ischemia-induced ventricular arrhythmias in mouse models?
In mouse models, dyscholesterolemia prolongs action potential duration by increasing L-type calcium current, thereby reducing the occurrence of ischemia-induced reentrant arrhythmias.
May attenuate ischemia-induced VT/VF in dyslipidemic mice; hypothesis-generating and should not alter clinical practice.
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Baartscheer et al. (2015) studied this question.
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