High-Dose Ifosfamide Is Associated with Severe, Reversible Cardiac Dysfunction

52 consecutive patients with advanced lymphoma or carcinoma enrolled in phase I trials of high-dose ifosfamide as part of combination chemotherapy with autologous bone marrow transplantation.

High-dose ifosfamide (escalating doses 10 to 18 g/m2) in combination with carboplatin and etoposide or with lomustine and vinblastine.

Incidence and occurrence of cardiac toxicity (clinical, radiographic, or electrocardiographic evidence of cardiovascular dysfunction).safety