Why the study?
Does propofol compared to isoflurane improve pulmonary mechanics and blood gases in patients with moderate to severe COPD undergoing anesthesia?
Population
60 patients with moderate to severe COPD
Comparison
Propofol as primary maintenance agent vs Isoflurane as primary maintenance agent
Design
RCT, randomly assigned
Follow-up
postoperative
Authors
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Supports either agent for maintenance anesthesia in moderate-severe COPD; confirms comparable pulmonary mechanics and oxygenation.
Does propofol compared to isoflurane improve pulmonary mechanics and blood gases in patients with moderate to severe COPD undergoing anesthesia?
Propofol and isoflurane have similar effects on pulmonary mechanics and oxygenation when used for anesthesia maintenance in patients with moderate to severe COPD, though they differ slightly in their effect on postoperative PaCO2.
DeSouza et al. (1995) studied this question.
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