Why the study?
The sympathetic nervous system is believed to be involved in kidney injury caused by heart failure, but direct evidence is still lacking.
Does sympathetic nerve activation protect against chronic renal fibrosis in preclinical models of cardiorenal syndrome?
Does sympathetic nerve activation protect against chronic renal fibrosis in preclinical models of cardiorenal syndrome?
Contrary to its harmful role in chronic renal fibrosis, sympathetic nerve activation may protect against renal fibrosis following ischemic insults in the setting of cardiorenal syndrome.
Sympathetic modulation in cardiorenal injury lacks direct evidence; hypothesis-generating and should not yet change practice.
The interactions between the kidney and heart are well studied and frequently lumped together as cardiorenal syndrome. It is believed that the sympathetic nervous system is involved in the mechanism of kidney injury caused by heart failure, but direct evidence is still lacking. In chronic renal fibrosis, sympathetic nerve activation was demonstrated to be harmful by unilateral ureteral obstruction and post-ischemia reperfusion injury models. On the other hand, sympathetic nerve activation seemed protective in acute kidney injury models such as ischemia reperfusion injury and lipopolysaccharide injection. Our recent investigation showed that post-ischemic renal fibrosis was attenuated when preexisting heart failure was induced by transverse aortic constriction surgery and renal denervation canceled this protection. These findings suggest sympathetic nerve activation in cardiorenal syndrome may be protective on chronic renal fibrosis development caused by ischemic an insult.
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Doi et al. (2023) studied this question.
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