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January 1, 2003Bioscience Biotechnology and BiochemistryOpen Access

cGMP-Phosphodiesterase Activity Is Up-regulated in Response to Pressure Overload of Rat Ventricles

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Population

Rat model of pressure overload (aortic banding)

Design

Preclinical

Follow-up

14 days

Authors

NYNoriyuki YanakaYKYukie KurosawaKMKouichi Minami

Discussion

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Overview

PDE1/2 upregulation may blunt cGMP in hypertrophied hearts; hypothesis-generating for PDE-targeted therapies in human pressure-overload disease.

Structured PICO

P
Population
Rat model of pressure overload (aortic banding)
I
Intervention
Aortic banding (pressure overload)
O
Outcome
cGMP level, PDE1 and PDE2 activities, and PDE1A/PDE2A mRNA levelssurrogate

Increased cGMP-PDE activity in response to pressure overload appears to be post-transcriptionally up-regulated and may play an important role in neutralizing cGMP action in hypertrophied cardiac tissue.

Cite This Study

Yanaka et al. (2003) studied this question.

synapsesocial.com/papers/6a7cfb499b79cb18d5cd8f07https://doi.org/10.1271/bbb.67.973
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy2000 · 159 citations
  2. 2Expression of Rat cGMP‐Binding cGMP‐Specific Phosphodiesterase mRNA in Purkinje Cell Layers During Postnatal Neuronal Development1997 · 91 citations
  3. 3Cloning and Characterization of a Novel Human Phosphodiesterase That Hydrolyzes Both cAMP and cGMP (PDE10A)1999 · 408 citations
  4. 4Natriuretic Peptides Inhibit DNA Synthesis in Cardiac Fibroblasts1995 · 273 citations
  5. 5Isolation and Characterization of cDNAs Corresponding to Two Human Calcium, Calmodulin-regulated, 3′,5′-Cyclic Nucleotide Phosphodiesterases1996 · 142 citations