Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 3, 2010PLoS ONEOpen Access

Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II

View Full Paper
Ask AI
Bookmark
Share

Population

Wistar male rats

Design

Preclinical

Follow-up

2 weeks

Authors

WMWalid MokniTKThérèse KeravisNÉNelly Étienne-Selloum

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for PDE1/PDE2 inhibition in hypertrophy; leaves open translation to human disease.

Structured PICO

P
Population
Wistar male rats
I
Intervention
Chronic infusion of angiotensin II using osmotic mini-pumps over two weeks
O
Outcome
PDE1 to PDE5 specific activities and protein and mRNA expressions in left cardiac ventriclessurrogate

In early cardiac hypertrophy induced by angiotensin II, specific PDE activities are increased, suggesting cGMP-PDEs (especially PDE1 and PDE2) may be therapeutic targets.

Cite This Study

Mokni et al. (2010) studied this question.

synapsesocial.com/papers/6a7cb4b580d29ce2cbfab77ahttps://doi.org/10.1371/journal.pone.0014227
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 22015 · 126 citations
  2. 2cGMP-Phosphodiesterase Activity Is Up-regulated in Response to Pressure Overload of Rat Ventricles2003 · 41 citations
  3. 3Role of Ca <sup>2+</sup> /Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy2009 · 173 citations
  4. 4Microdomain Switch of cGMP-Regulated Phosphodiesterases Leads to ANP-Induced Augmentation of β-Adrenoceptor-Stimulated Contractility in Early Cardiac Hypertrophy2015 · 102 citations
  5. 5NO-induced cGMP in the heart: Role of phosphodiesterases in physiology and pathophysiology2024