Key result
Inhibition of PDE2 exerts an antihypertrophic effect by generating a local pool of cAMP, contrasting with the hypertrophic effects of PDE3 and PDE4 inhibition.
Why the study?
Does PDE2 inhibition prevent cardiac hypertrophy in cardiac myocytes?
Population
Cardiac myocytes (in vitro and in vivo models)
Comparison
Pharmacological and genetic inhibition of… vs Inhibition of PDE3 and PDE4, or control
Design
Preclinical
Authors
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PDE2 inhibition merits exploration as antihypertrophic target; leaves open translation from myocyte data to clinical use.
Does PDE2 inhibition prevent cardiac hypertrophy in cardiac myocytes?
PDE2 inhibition exerts an antihypertrophic effect on cardiac myocytes by generating a local pool of cAMP, suggesting a potential therapeutic target for cardiac hypertrophy.
Zoccarato et al. (2015) studied Cardiac hypertrophy. PDE2 inhibition vs. PDE3 and PDE4 inhibition was evaluated on Cardiac myocyte hypertrophic growth. Inhibition of PDE2 exerts an antihypertrophic effect by generating a local pool of cAMP, contrasting with the hypertrophic effects of PDE3 and PDE4 inhibition.
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