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February 16, 2015Circulation Research

Microdomain Switch of cGMP-Regulated Phosphodiesterases Leads to ANP-Induced Augmentation of β-Adrenoceptor-Stimulated Contractility in Early Cardiac Hypertrophy

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Population

Mice with early cardiac hypertrophy induced by transverse aortic constriction and transgenic mice expressing…

Design

Preclinical

Authors

RPRuwan K. PereraJSJulia SprengerJSJulia H. Steinbrecher

Discussion

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Overview

Potential compensatory mechanism in early hypertrophy; hypothesis-generating for PDE-targeted cGMP modulation in human HF.

Structured PICO

P
Population
Mice with early cardiac hypertrophy induced by transverse aortic constriction (TAC) and transgenic mice expressing a membrane-targeted FRET-based biosensor
I
Intervention
Atrial natriuretic peptide (ANP) stimulation
O
Outcome
β-adrenergic receptor-stimulated cardiomyocyte contractility and cAMP/cGMP microdomain signalingsurrogate

Redistribution of cGMP-regulated phosphodiesterases in early cardiac hypertrophy augments cGMP-mediated contractility, representing a potential compensatory mechanism to sustain heart function.

Cite This Study

Perera et al. (2015) studied this question.

synapsesocial.com/papers/6a8b9d42e76aab331233833dhttps://doi.org/10.1161/circresaha.116.306082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 22015 · 127 citations
  2. 2Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II2010 · 63 citations
  3. 3Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy2023 · 29 citations
  4. 4Imaging alterations of cardiomyocyte cAMP microdomains in disease2015 · 26 citations
  5. 5Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS22010 · 87 citations