March 1, 2004Current Gene Therapy

Exploiting Internal Ribosome Entry Sites in Gene Therapy Vector Design

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Design

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Authors

SNS-M NgoiNational University of Singapore ACAnna L. ChienJohns Hopkins University CLCaroline LeeNational University of Singapore

Discussion

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Implication

May support IRES use for multi-gene co-expression in therapy vectors; leaves open clinical translation pending prospective trials.

Structured PICO

Intervention

Internal Ribosome Entry Sites (IRES) in gene therapy vectors

The incorporation of IRES into gene therapy vectors is a promising strategy for co-expressing multiple genes, which is necessary for treating complex disorders and infectious diseases.

Cite This Study

Ngoi et al. (2004) studied this question.

synapsesocial.com/papers/6a7cfe0a3d640844b95e05b0 https://doi.org/10.2174/1566523044578095

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Exploiting Internal Ribosome Entry Sites in Gene Therapy Vector Design

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Exploiting Internal Ribosome Entry Sites in Gene Therapy Vector Design

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider