March 1, 1996Journal of VirologyOpen Access

Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity

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Population

HeLa cells and in vitro translation systems programmed by poliovirus (PV) 5' untranslated region (UTR)

Comparison

I-RNA and its smaller fragments vs Inactive I-RNA mutants

Design

Preclinical

Authors

SDSaumitra DasIndian Institute of Science Bangalore DBD Bocskai JKJack D. KeeneDuke Medical Center

Discussion

Member takes

Implication

May guide IRES-targeted antivirals; leaves open in vivo efficacy and clinical translation.

Structured PICO

Population

HeLa cells and in vitro translation systems programmed by poliovirus (PV) 5' untranslated region (UTR)

Intervention

I-RNA (60-nucleotide RNA from Saccharomyces cerevisiae) and its smaller fragments (16 and 25 nucleotides)

Comparator

Inactive I-RNA mutants

Outcome

Inhibition of cap-independent, internal ribosome entry site (IRES)-mediated translationsurrogate

Specific sequences within a small yeast RNA, interacting with human La autoantigen and other proteins, are required for inhibiting poliovirus IRES-mediated translation.

Cite This Study

Das et al. (1996) studied this question.

synapsesocial.com/papers/6a7cfe0a3d640844b95e05b9 https://doi.org/10.1128/jvi.70.3.1624-1632.1996

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Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider