Key result
A small yeast RNA (I-RNA) selectively inhibited internal initiation of translation programmed by poliovirus RNA and efficiently inhibited the replication of poliovirus RNA in transfected HeLa cells.
Population
In vitro translation systems and HeLa cells
Design
Preclinical
Authors
Loading...
Selectively blocks IRES-driven viral translation; leaves open therapeutic potential of synthetic analogs.
A small yeast RNA selectively inhibits poliovirus RNA translation and replication by blocking internal ribosome entry.
Das et al. (1994) studied Poliovirus infection. Yeast inhibitor RNA (I-RNA) was evaluated on Inhibition of translation by internal ribosome entry and replication of poliovirus RNA. A small yeast RNA (I-RNA) selectively inhibited internal initiation of translation programmed by poliovirus RNA and efficiently inhibited the replication of poliovirus RNA in transfected HeLa cells.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: