Population
Saccharomyces cerevisiae (yeast) model and in vitro translation systems
Design
Preclinical
Authors
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IRNA structural motifs may guide IRES inhibitor design; leaves open translation from animal models to clinical use.
The secondary structure of IRNA, specifically the main stem and one loop, is critical for its ability to bind trans-acting proteins and selectively inhibit IRES-mediated translation.
Venkatesan et al. (1999) studied this question.
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