July 1, 1998Journal of VirologyOpen Access

A Small Yeast RNA Blocks Hepatitis C Virus Internal Ribosome Entry Site (HCV IRES)-Mediated Translation and Inhibits Replication of a Chimeric Poliovirus under Translational Control of the HCV IRES Element

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Population

Human hepatoma (Huh-7) cell lines and in vitro models

Comparison

Small yeast RNA (IRNA) expression vs Control hepatoma cells not expressing IRNA

Design

Preclinical

Authors

SDSaumitra DasIndian Institute of Science Bangalore MOMichael OttMedizinische Hochschule Hannover AYAkemi YamaneCedars-Sinai Medical Center

Discussion

Member takes

Implication

IRNA may represent a novel HCV therapeutic lead; leaves open in vivo efficacy and clinical translation.

Structured PICO

Population

Human hepatoma (Huh-7) cell lines and in vitro models

Intervention

Small yeast RNA (IRNA) expression

Comparator

Control hepatoma cells not expressing IRNA

Outcome

Inhibition of HCV IRES-mediated translation and replication of PV-HCV chimerasurrogate

A small yeast RNA (IRNA) specifically inhibits HCV IRES-mediated translation and viral replication in vitro, suggesting a potential novel therapeutic target for HCV infection.

Cite This Study

Das et al. (1998) studied this question.

synapsesocial.com/papers/6a7cfe0a3d640844b95e05b3 https://doi.org/10.1128/jvi.72.7.5638-5647.1998

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A Small Yeast RNA Blocks Hepatitis C Virus Internal Ribosome Entry Site (HCV IRES)-Mediated Translation and Inhibits Replication of a Chimeric Poliovirus under Translational Control of the HCV IRES Element

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Small Yeast RNA Blocks Hepatitis C Virus Internal Ribosome Entry Site (HCV IRES)-Mediated Translation and Inhibits Replication of a Chimeric Poliovirus under Translational Control of the HCV IRES Element

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider