July 16, 2004Nucleic Acids ResearchOpen Access

Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs)

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Population

Cells transfected with Hepatitis C virus (HCV) internal ribosomal entry site (IRES) sequences

Design

Preclinical

Authors

CNChristopher J. NulfThe University of Texas Southwestern Medical Center

Discussion

Member takes

Implication

Hypothesis-generating for PNA/LNA-based HCV antivirals; prospective studies needed before clinical adoption.

Structured PICO

Population

Cells transfected with Hepatitis C virus (HCV) internal ribosomal entry site (IRES) sequences

Intervention

Antisense peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers (15-21 bases) introduced via lipid-mediated transfections

Outcome

Inhibition of translationsurrogate

PNAs and LNAs can invade critical sequences within the HCV IRES and inhibit translation, providing potential therapeutic lead compounds for HCV treatment.

Cite This Study

Christopher J. Nulf (2004) studied this question.

synapsesocial.com/papers/6a72a9403ce530166bc35bf4 https://doi.org/10.1093/nar/gkh706

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Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider