December 1, 2001The Journal of Clinical Endocrinology & MetabolismOpen Access

β-Adrenergic Regulation of IL-6 Release from Adipose Tissue:In Vivoandin VitroStudies

View Full Paper

Ask AI

Bookmark

Why the study?

Does beta-adrenergic stimulation increase IL-6 release from adipose tissue?

Structured PICO

Does beta-adrenergic stimulation increase IL-6 release from adipose tissue?

Population

Human volunteers (n=8, 4 male/4 female, mean age 35.5, BMI 24.6), C57BL6/J male mice, human peripheral blood cells, isolated human adipocytes, and differentiated 3T3F442A adipocytes.

Intervention

Beta-adrenergic agonists (isoproterenol, norepinephrine in humans; dobutamine, clenbuterol, CL316243 in mice; isoproterenol, norepinephrine, lipopolysaccharide in vitro)

Comparator

Saline placebo or untreated controls

Outcome

Plasma IL-6 levels or IL-6 secretionsurrogate

Beta 2/beta 3 adrenoceptor stimulation on adipocytes increases IL-6 secretion, suggesting a mechanism for elevated IL-6 during sympathetic activation and obesity.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May raise IL-6 via adipocyte beta-receptors; hypothesis-generating for sympathetic activation in obesity and needs human confirmation.

Cite This Study

Mohamed‐Ali et al. (2001) studied this question.

synapsesocial.com/papers/6a7cfe17dd834592f30eb7a0 https://doi.org/10.1210/jcem.86.12.8104

View Full Paper

Ask AI

Bookmark

β-Adrenergic Regulation of IL-6 Release from Adipose Tissue:In Vivoandin VitroStudies

Structured PICO

Discussion

Implication

Cite This Study

β-Adrenergic Regulation of IL-6 Release from Adipose Tissue:In Vivoandin VitroStudies

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider