May 11, 2004Arteriosclerosis Thrombosis and Vascular Biology

Angiotensin II Stimulates the Release of Interleukin-6 and Interleukin-8 From Cultured Human Adipocytes by Activation of NF-κB

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Population

in vitro differentiated human adipocytes

Design

Preclinical

Authors

TSThomas SkurkKlinikum rechts der Isar VHVanessa van HarmelenLeiden University Medical Center HHHans HaunerTechnical University of Munich

Discussion

Member takes

Implication

Supports Ang II-driven adipocyte inflammation via AT1/NF-kappaB; leaves open relevance to human cardiometabolic disease.

Structured PICO

Population

in vitro differentiated human adipocytes

Intervention

Angiotensin II

Outcome

IL-6 and IL-8 mRNA expression and protein releasesurrogate

Angiotensin II stimulates the production and release of proinflammatory cytokines IL-6 and IL-8 from human adipocytes via an AT1 receptor-mediated, NF-kappaB-dependent pathway.

Cite This Study

Skurk et al. (2004) studied this question.

synapsesocial.com/papers/6a7f1e640d396ca0cf0fc87d https://doi.org/10.1161/01.atv.0000131266.38312.2e

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Angiotensin II Stimulates the Release of Interleukin-6 and Interleukin-8 From Cultured Human Adipocytes by Activation of NF-κB

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Stimulates the Release of Interleukin-6 and Interleukin-8 From Cultured Human Adipocytes by Activation of NF-κB

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider