Population
Human primary cultured preadipocytes
Design
Preclinical
Authors
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Hypothesis-generating in preclinical models; leaves open any role for Ang II modulation in human cardiometabolic disease.
Angiotensin II reduces insulin-induced differentiation of human preadipocytes and downregulates angiotensinogen and renin gene expression, suggesting a potential protective role against uncontrolled adipose tissue expansion.
Schling et al. (2001) studied this question.
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