What does this research mean for the field?

Human adipose tissue expresses angiotensinogen and the enzymes of both the renin-angiotensin and nonrenin-angiotensin systems required for its conversion to angiotensin II. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

To analyze the expression of angiotensinogen and its conversion enzymes in human adipose tissue.

November 1, 1998The Journal of Clinical Endocrinology & MetabolismOpen Access

Human Adipose Tissue Expresses Angiotensinogen and Enzymes Required for Its Conversion to Angiotensin II1

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Obesity (n=9). Primary outcome: Expression of angiotensinogen and enzymes required for its conversion to angiotensin II.

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Key result

Analysis of human adipose tissue from 9 obese subjects demonstrated the expression of angiotensinogen and enzymes of the renin-angiotensin and nonrenin-angiotensin systems.

Authors

CKCecilia KarlssonAstraZeneca (Finland)KLKajsa LindellSahlgrenska University Hospital MOMalin OttossonSahlgrenska University Hospital

Discussion

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Implication

May implicate local adipose angiotensin production in obesity; leaves open its role in cardiometabolic disease.

Key Points

To analyze the expression of angiotensinogen and its conversion enzymes in human adipose tissue.
Northern blot analysis of angiotensinogen expression in adipose tissue from nine obese subjects.
Western blot to confirm the presence of angiotensinogen protein in isolated adipocytes.
RT-PCR and Southern blot to detect renin and angiotensin-converting enzyme expression.
Angiotensinogen expressed in adipose tissue with a distinct protein band at 61 kDa.
Renin and angiotensin-converting enzyme messenger RNA detected in human adipose tissue.
Transcripts for cathepsin D and G from the non-renin-angiotensin system also detected.

Study Design

Type

Observational (n=9)

PICO

Population

Obesity (n=9)

Primary Outcome

Expression of angiotensinogen and enzymes required for its conversion to angiotensin II

Cite This Study

Karlsson et al. (1998) conducted an observational in Obesity (n=9). Analysis of human adipose tissue from 9 obese subjects demonstrated the expression of angiotensinogen and enzymes of the renin-angiotensin and nonrenin-angiotensin systems.

synapsesocial.com/papers/6a16b4c64f6063e06b050cfd https://doi.org/10.1210/jcem.83.11.5276

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Human Adipose Tissue Expresses Angiotensinogen and Enzymes Required for Its Conversion to Angiotensin II1

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

Human Adipose Tissue Expresses Angiotensinogen and Enzymes Required for Its Conversion to Angiotensin II1

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

Also Consider

Also Consider