What does this research mean for the field?

Subcutaneous adipose angiotensinogen gene expression is significantly elevated in obese men and correlates positively with body weight. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aimed to investigate the relationship between adipose angiotensinogen gene expression and human obesity.

July 1, 2000Obesity Research

Increased Adipose Angiotensinogen Gene Expression in Human Obesity

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Why the study?

Is subcutaneous adipose angiotensinogen gene expression associated with human obesity?

Population

17 men undergoing either gastric banding for obesity or elective laparoscopic cholecystectomy

Design

Cross-sectional

Authors

VHVanessa van HarmelenLeiden University Medical Center PAParisa AriapartKarolinska Institutet JHJohan HoffstedtUniversity of Geneva

Discussion

Member takes

Implication

Supports association of adipose angiotensinogen with obesity but should not change practice; leaves open causal role in adipose expansion.

Key Points

This research aimed to investigate the relationship between adipose angiotensinogen gene expression and human obesity.
Study group of 17 men undergoing either gastric banding or elective laparoscopic cholecystectomy
Measured adipose angiotensinogen mRNA and 18S ribosomal RNA levels using competitive quantitative reverse transcriptase-polymerase chain reaction
Participants included 7 obese and 10 non-obese men with varying body mass indexes.
Adipose angiotensinogen mRNA expression was about two times increased in obese men compared to non-obese men.
No significant difference in 18S rRNA levels between the two groups was observed.
Body weight positively correlated with adipose angiotensinogen mRNA expression after adjusting for age and height.

Structured PICO

Is subcutaneous adipose angiotensinogen gene expression associated with human obesity?

Population

17 men undergoing either gastric banding for obesity or elective laparoscopic cholecystectomy (7 obese, 10 non-obese men; body mass index 22 to 51 kg/m2; age 26 to 68 years)

Comparator

Non-obese men

Outcome

Subcutaneous adipose angiotensinogen mRNA levelssurrogate

Adipose angiotensinogen gene expression is elevated in obese men, suggesting a potential role in adipose tissue growth and development.

Cite This Study

Harmelen et al. (2000) studied this question.

synapsesocial.com/papers/6a1bcf23ea84844e355f00f1 https://doi.org/10.1038/oby.2000.40

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Implication

Supports association of adipose angiotensinogen with obesity but should not change practice; leaves open causal role in adipose expansion.

Increased Adipose Angiotensinogen Gene Expression in Human Obesity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Increased Adipose Angiotensinogen Gene Expression in Human Obesity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider