Key result
Angiotensin II reduced the adipogenic response of omental adipocyte progenitor cells more in obese donors (56.3% reduction) than in non-obese donors (44.5% reduction) (p<0.01).
Absolute Event Rate: 56.3% vs 44.5%
p-value: p=<0.01
Angiotensin II exerts a greater anti-adipogenic effect on omental adipose progenitor cells from obese subjects compared to non-obese subjects, an effect reversible by losartan.
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Supports obesity-dependent modulation of adipogenesis by Ang II; leaves open whether RAS blockade alters adipose progenitor function in patients.
Brücher et al. (2007) studied Obesity. Angiotensin II vs. Non-obese donors' cells was evaluated on Reduction of adipogenesis (measured by glycerol-3-phosphate dehydrogenase activity) (p=<0.01). Angiotensin II reduced the adipogenic response of omental adipocyte progenitor cells more in obese donors (56.3% reduction) than in non-obese donors (44.5% reduction) (p<0.01).