What does this research mean for the field?

Angiotensin-converting enzyme mRNA is expressed in human subcutaneous and extraperitoneal adipose tissue and localized in adipocytes, suggesting the presence of a local renin-angiotensin system. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to investigate the expression and localization of the angiotensin-converting enzyme gene in human adipose tissue.

January 1, 1994Blood Pressure

The Expression and Localisation of the Angiotensin-Converting Enzyme mRNA in Human Adipose Tissue

Q: What is the clinical evidence from this study?

Study design: Other. Primary outcome: Expression and localisation of angiotensin-converting enzyme mRNA.

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Key result

Angiotensin-converting enzyme mRNA is expressed in human subcutaneous and extraperitoneal adipose tissue and localized in adipocytes, suggesting a local renin-angiotensin system.

Authors

JJJulie R. JonssonUNSW Sydney PGPhilip A. GameMonash University RHRichard HeadJames S. McDonnell Foundation

Discussion

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Implication

No immediate clinical implications for hypertension management; extends rodent data on adipose RAS to human tissue.

Key Points

The aim is to investigate the expression and localization of the angiotensin-converting enzyme gene in human adipose tissue.
Northern analysis was used to detect mRNA levels for angiotensin-converting enzyme.
In situ hybridization was employed to identify the localization of gene expression in adipocytes.
Angiotensin-converting enzyme mRNA was found in both subcutaneous and extraperitoneal adipose tissue.
The angiotensin-converting enzyme gene was specifically expressed in adipocytes.

PICO

Primary Outcome

Expression and localisation of angiotensin-converting enzyme mRNA

Cite This Study

Jonsson et al. (1994) studied this question. Angiotensin-converting enzyme mRNA is expressed in human subcutaneous and extraperitoneal adipose tissue and localized in adipocytes, suggesting a local renin-angiotensin system.

synapsesocial.com/papers/6a15ccd3a2352da34782ecaa https://doi.org/10.3109/08037059409101524

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The Expression and Localisation of the Angiotensin-Converting Enzyme mRNA in Human Adipose Tissue

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

The Expression and Localisation of the Angiotensin-Converting Enzyme mRNA in Human Adipose Tissue

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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