Key result
The proximal promoter element from -96 to -52 of the angiotensinogen gene plays a critical role in its adipogenic activation by binding to a nuclear factor induced during differentiation.
Population
3T3-L1 preadipocyte-adipocyte system
Comparison
Adipogenic differentiation vs Undifferentiated preadipocytes
Design
Preclinical
Authors
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No change to hypertension care; leaves open this promoter element's role in human adipocyte angiotensinogen regulation.
Identifies the specific proximal promoter region (-96 to -52) responsible for the activation of the angiotensinogen gene during adipocyte differentiation.
Tamura et al. (1994) studied Adipogenesis. Adipogenic differentiation was evaluated on Angiotensinogen gene expression and promoter activity. The proximal promoter element from -96 to -52 of the angiotensinogen gene plays a critical role in its adipogenic activation by binding to a nuclear factor induced during differentiation.
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