Population
Cerebral parenchymal arterioles within brain slices from hypertensive and normotensive rats
Comparison
Potassium chloride and sodium nitroprusside vs Normotensive rats compared to hypertensive rats
Design
Preclinical
Authors
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Augmented Kir-mediated vasodilation in hypertensive rats may reflect vascular adaptation; leaves open translation to human cerebrovascular therapy.
Inward rectifier K+ channels play a crucial role in vasodilation produced by extracellular K+ in cerebral microvessels, and this vasodilator response is augmented in chronic hypertension.
Nakahata et al. (2006) studied this question.
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