February 16, 2013Journal of Hypertension
High-sensitivity troponin T predicts worsening of albuminuria in hypertension; results of a nested case–control study with confirmation in diabetes
Why the study?
Does baseline high-sensitivity troponin T predict the transition in albuminuria stage in patients with hypertension or type 2 diabetes?
Population
75 case/control pairs with hypertension and 33 case/control pairs with type 2 diabetes extracted from a…
Comparison
Higher baseline high-sensitivity troponin T levels vs Lower baseline high-sensitivity troponin T levels
Design
Case-control
Follow-up
average 2.8 years
Authors
Discussion
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Member takes
Implication
hs-TnT may flag higher albuminuria transition risk in hypertension or diabetes; hypothesis-generating and requires validation before clinical adoption.
Structured PICO
Does baseline high-sensitivity troponin T predict the transition in albuminuria stage in patients with hypertension or type 2 diabetes?
P
Population
75 case/control pairs with hypertension and 33 case/control pairs with type 2 diabetes (T2DM) extracted from a general population cohort (PREVEND-study, N=8592). Cases were defined by transition in albuminuria stage; controls had stable albuminuria and were pair-matched for age, sex, and albuminuria-status.
I
Intervention
Higher baseline high-sensitivity troponin T (hs-TnT) levels
C
Comparator
Lower baseline high-sensitivity troponin T (hs-TnT) levels
O
Outcome
Transition in albuminuria stage (from normoalbuminuria to microalbuminuria or from microalbuminuria to macroalbuminuria)surrogate
High-sensitivity troponin T is an independent marker that predicts the worsening of albuminuria in patients with hypertension and type 2 diabetes, potentially allowing for earlier intervention.
Cite This Study
Hellemons et al. (2013) studied this question.