Why the study?
Is the elevated ET-1 concentration in chronic heart failure caused by increased production or decreased clearance?
Is the elevated ET-1 concentration in chronic heart failure caused by increased production or decreased clearance?
Elevated ET-1 concentrations in chronic heart failure are driven by increased production rather than decreased clearance.
Authors
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Supports excess ET-1 production as driver of elevation in CHF; leaves open whether production-targeted therapies improve outcomes.
Parker et al. (2004) studied this question.
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