Why the study?
Does heart transplantation improve survival in patients with radiation-induced end-stage heart failure?
Does heart transplantation improve survival in patients with radiation-induced end-stage heart failure?
Heart transplantation appears to be a viable and encouraging treatment option for patients with end-stage heart failure induced by mediastinal radiation therapy, with excellent short- and intermediate-term survival.
May support heart transplantation in radiation-induced end-stage HF; leaves open confirmation in larger prospective studies.
Radiation-induced heart disease is an increasingly recognized late sequela of mediastinal radiation therapy for malignant neoplasms. We report four cases of heart transplantation for end-stage heart failure induced by mediastinal radiation therapy. Short-term and intermediate-term results are excellent with all four patients currently surviving a mean of 48 months after transplantation. Neither a second malignancy nor recurrence of the primary malignancy has been observed to date. The early results of heart transplantation for end-stage, radiation-induced heart disease are encouraging.
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Handa et al. (2000) studied this question.
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