June 1, 2005Diabetes
Albumin Excretion Rate and Cardiovascular Risk
Key result
A dominant early peak in postischemic skin flow was associated with a higher albumin excretion rate (12.6 vs 3.7 microg/min in normal; P<0.001 for trend) and increased cardiovascular risk factors.
Why the study?
Is a rapid peak flow response after ischemia associated with elevated albumin excretion rate and cardiovascular risk factors?
Population
305 individuals (188 without diabetes and 117 with diabetes)
Comparison
Measurement of skin flow in response to arterial… vs Comparison between three patterns of…
Design
Cross-sectional
Authors
Discussion
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Implication
May signal shared microvascular dysfunction in diabetes; hypothesis-generating and should not yet change practice.
Study Design
Type
Cross-Sectional (n=305)
Structured PICO
Is a rapid peak flow response after ischemia associated with elevated albumin excretion rate and cardiovascular risk factors?
P
Population
305 individuals with and without diabetes assessed for postischemic skin flow patterns and albumin excretion rate.
E
Exposure
Measurement of skin flow (flux) in response to arterial occlusion (ischemia) using Laser Doppler fluximetry
C
Comparator
Comparison between three patterns of postischemic peak flow: gradual rise to peak (normal), nondominant early peak, and dominant early peak
O
Outcome
Albumin excretion rate (AER) calculated from a timed overnight urine collection and its association with cardiovascular risk factorssurrogate
Main Result
Absolute Event Rate: 12.6% vs 3.7%
p-value: p=<0.001 for trend
A rapid peak flow response after ischemia is associated with elevated albumin excretion rate and cardiovascular risk factors, suggesting shared microvascular dysfunction pathways.
Cite This Study
Strain et al. (2005) conducted a cross-sectional in Diabetes and non-diabetes (n=305). Dominant early peak in postischemic skin flow vs. Normal gradual rise to peak or nondominant early peak was evaluated on Albumin excretion rate (AER) (p=<0.001 for trend). A dominant early peak in postischemic skin flow was associated with a higher albumin excretion rate (12.6 vs 3.7 microg/min in normal; P<0.001 for trend) and increased cardiovascular risk factors.