What question did this study set out to answer?

To investigate the relationship between urinary albumin levels and cardiovascular mortality in postmenopausal women.

June 26, 2001CirculationOpen Access

Excessive Urinary Albumin Levels Are Associated With Future Cardiovascular Mortality in Postmenopausal Women

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Why the study?

Are excessive urinary albumin levels associated with future cardiovascular mortality in postmenopausal women?

Population

12,239 postmenopausal women from the general population in Utrecht, the Netherlands. Nested case-control…

Comparison

Highest quintile of urinary albumin levels vs No detectable urinary albumin

Design

Case-control

Follow-up

between 1976 and 1995

Authors

MRMark RoestMithra Pharmaceuticals (Belgium)JBJan Dirk BangaZiekenhuis Gelderse Vallei WJWilbert M.T. JanssenMartini Ziekenhuis

Discussion

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Implication

Elevated urinary albumin was associated with higher cardiovascular mortality in postmenopausal women; hypothesis-generating and requires prospective confirmation before guiding practice.

Key Points

To investigate the relationship between urinary albumin levels and cardiovascular mortality in postmenopausal women.
Analyzed a cohort of 12,239 postmenopausal women aged 52-67 from Utrecht, Netherlands.
Followed women for vital status over 19 years (1976-1995) with 561 cases and 557 controls evaluated for urinary albumin.
Used nested case-control design to analyze cardiovascular mortality rates based on urinary albumin levels.
Women in the highest quintile of urinary albumin had a cardiovascular mortality rate of 13.2/1000 years (95% CI 8.1-20.9).
Women without detectable urinary albumin had a mortality rate of 2.6/1000 years (95% CI 2.3-3.1).
Age-adjusted rate ratio for cardiovascular mortality between the two groups was found to be 4.4 (95% CI 2.6-7.6).

Structured PICO

Are excessive urinary albumin levels associated with future cardiovascular mortality in postmenopausal women?

Population

12,239 postmenopausal women (initial age 52-67 years) from the general population in Utrecht, the Netherlands. Nested case-control analysis included 561 cases and 557 controls.

Intervention

Highest quintile of urinary albumin levels

Comparator

No detectable urinary albumin

Outcome

Cardiovascular mortalityhard clinical

Microalbuminuria is a strong, independent predictor of future cardiovascular mortality in postmenopausal women, suggesting it reflects early vascular damage.

Cite This Study

Roest et al. (2001) studied this question.

synapsesocial.com/papers/6a70ecb52163a0a01bc52059 https://doi.org/10.1161/hc2501.091353

Topics

Women and heart disease Hypertension management

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Implication

Elevated urinary albumin was associated with higher cardiovascular mortality in postmenopausal women; hypothesis-generating and requires prospective confirmation before guiding practice.

Excessive Urinary Albumin Levels Are Associated With Future Cardiovascular Mortality in Postmenopausal Women

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Excessive Urinary Albumin Levels Are Associated With Future Cardiovascular Mortality in Postmenopausal Women

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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