Key result
Elevated urinary albumin excretion linked to ~2-fold higher risk of coronary heart disease and death.
Why the study?
The lower cutoff level of urinary albumin excretion associated with increased risk of coronary heart disease and death is unknown, and it is unclear whether impaired renal function confounds this association.
Does urinary albumin excretion >4.8 microg/min increase the risk of coronary heart disease and death in adults aged 30-70?
Population
2762 men and women aged 30 to 70 years from the Third Copenhagen City Heart Study
Comparison
Urinary albumin excretion >4.8 microg/min vs lower levels (≤4.8 microg/min)
Design
Prospective cohort study
Follow-up
Until 1999 for coronary heart disease and until 2001 for death
Authors
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Low-level albuminuria signals higher CHD and mortality risk; leaves open whether lowering diagnostic thresholds improves outcomes.
Cohort (n=2,762)
Does urinary albumin excretion >4.8 microg/min increase the risk of coronary heart disease and death in adults aged 30-70?
Relative Risk: 2 (95% CI 1.4–3)
p-value: p=<0.001
Very low levels of microalbuminuria (>4.8 microg/min) are a strong, independent predictor of coronary heart disease and death, suggesting a need to lower the threshold for defining microalbuminuria.
Klausen et al. (2004) reported a cohort. Urinary albumin excretion >4.8 microg/min vs. Urinary albumin excretion ≤4.8 microg/min was evaluated on Coronary heart disease (RR 2.0, 95% CI 1.4-3.0, p=<0.001). Urinary albumin excretion >4.8 microg/min was independently associated with an increased risk of coronary heart disease (RR 2.0; 95% CI 1.4-3.0) and death (RR 1.9; 95% CI 1.5-2.4).
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