What question did this study set out to answer?

To evaluate the diagnostic accuracy of plasma glial fibrillary acidic protein (GFAP) for differentiating intracerebral hemorrhage from ischemic stroke within 4.5 hours of acute symptom onset.

November 29, 2011Clinical ChemistryOpen Access

Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein for Differentiating Intracerebral Hemorrhage and Cerebral Ischemia in Patients with Symptoms of Acute Stroke

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Authors

CFChristian FoerchGoethe University Frankfurt MNMarion NiessnerRoche Pharma AG (Germany)TBTobias BackSpringer Nature (Germany)

Discussion

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Overview

Prospective multicenter study demonstrates high accuracy of plasma GFAP in differentiating hemorrhagic from ischemic stroke, indicating potential for rapid acute triage.

Key Points

To evaluate the diagnostic accuracy of plasma glial fibrillary acidic protein (GFAP) for differentiating intracerebral hemorrhage from ischemic stroke within 4.5 hours of acute symptom onset.
Prospective multicenter study enrolling 205 patients with suspected acute hemispheric stroke (symptom onset <4.5 hours before admission) across 14 stroke centers in Germany and Switzerland over a 1-year period.
Blood samples were drawn upon hospital admission to quantify plasma GFAP levels using an electrochemiluminometric immunoassay, with final discharge diagnosis classified as intracerebral hemorrhage (ICH), ischemic stroke, or stroke mimic.
Plasma GFAP levels were significantly higher in patients with ICH (n=39) compared to ischemic stroke (n=163) [median 1.91 μg/L (IQR 0.41–17.66) vs 0.08 μg/L (IQR 0.02–0.14), P<0.001].
GFAP demonstrated high diagnostic accuracy for differentiating ICH from ischemic stroke and mimics, yielding an area under the curve of 0.915 (95% CI 0.847–0.982, P<0.001).
A plasma GFAP cutoff value of 0.29 μg/L yielded a diagnostic sensitivity of 84.2% and a specificity of 96.3%.

Cite This Study

Foerch et al. (2011) studied this question.

synapsesocial.com/papers/6a7d088ce6f633beba6e44ab https://doi.org/10.1373/clinchem.2011.172676

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November 29, 2011Clinical ChemistryOpen Access

Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein for Differentiating Intracerebral Hemorrhage and Cerebral Ischemia in Patients with Symptoms of Acute Stroke

View Full Paper

Ask AI

Bookmark

Authors

CFChristian FoerchGoethe University Frankfurt MNMarion NiessnerRoche Pharma AG (Germany)TBTobias BackSpringer Nature (Germany)

Discussion

Member takes

Overview

Prospective multicenter study demonstrates high accuracy of plasma GFAP in differentiating hemorrhagic from ischemic stroke, indicating potential for rapid acute triage.

Key Points

To evaluate the diagnostic accuracy of plasma glial fibrillary acidic protein (GFAP) for differentiating intracerebral hemorrhage from ischemic stroke within 4.5 hours of acute symptom onset.
Prospective multicenter study enrolling 205 patients with suspected acute hemispheric stroke (symptom onset <4.5 hours before admission) across 14 stroke centers in Germany and Switzerland over a 1-year period.
Blood samples were drawn upon hospital admission to quantify plasma GFAP levels using an electrochemiluminometric immunoassay, with final discharge diagnosis classified as intracerebral hemorrhage (ICH), ischemic stroke, or stroke mimic.
Plasma GFAP levels were significantly higher in patients with ICH (n=39) compared to ischemic stroke (n=163) [median 1.91 μg/L (IQR 0.41–17.66) vs 0.08 μg/L (IQR 0.02–0.14), P<0.001].
GFAP demonstrated high diagnostic accuracy for differentiating ICH from ischemic stroke and mimics, yielding an area under the curve of 0.915 (95% CI 0.847–0.982, P<0.001).
A plasma GFAP cutoff value of 0.29 μg/L yielded a diagnostic sensitivity of 84.2% and a specificity of 96.3%.

Cite This Study

Foerch et al. (2011) studied this question.

synapsesocial.com/papers/6a7d088ce6f633beba6e44ab https://doi.org/10.1373/clinchem.2011.172676

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