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November 25, 2016Scientific ReportsOpen Access

Ligation of aortocaval fistula significantly attenuated pulmonary blood flow and right ventricular mass, and potentiated the isometric contraction of pulmonary artery.

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Why the study?

Does ligation of the aortocaval fistula improve cardiopulmonary morphometric functions in rats with flow-induced pulmonary hypertension?

Population

Rats with flow-induced pulmonary hypertension

Design

Preclinical

Authors

CHChih‐Hsin HsuJRJun‐Neng RoanJCJyh-Hong Chen

Discussion

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Overview

Suggests shunt correction may reverse experimental PH remodeling in rats; leaves open human translation and clinical relevance.

Structured PICO

Does ligation of the aortocaval fistula improve cardiopulmonary morphometric functions in rats with flow-induced pulmonary hypertension?

P
Population
Rats with flow-induced pulmonary hypertension
I
Intervention
Ligation of the aortocaval fistula
O
Outcome
Cardiopulmonary morphometric functions and phenotypic switching of pulmonary vascular smooth muscle cells (VSMC)surrogate

Correction of a systemic left-to-right shunt in a rat model reverses right ventricular and pulmonary artery remodeling by inducing transdifferentiation of pulmonary VSMCs to contractile phenotypes and modulating inflammatory cytokines.

Cite This Study

Hsu et al. (2016) studied this question.

synapsesocial.com/papers/6a7d08cc2d005ba2c41cc4e8https://doi.org/10.1038/srep37684
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Segmental pulmonary vascular remodeling in heart failure induced by chronic volume overload2026
  2. 2Regression of cardiac hypertrophy after closing an aortocaval fistula in rats1995 · 45 citations
  3. 3Murine Aortopulmonary Shunt Model of Flow-Driven Pulmonary Hypertension2026 · 1 citations
  4. 4PULMONARY VASCULAR REMODELING DISTAL TO PULMONARY ARTERY LIGATION IS ACCOMPANIED BY UPREGULATION OF ENDOTHELIN RECEPTORS AND NITRIC OXIDE SYNTHASE2000 · 61 citations
  5. 5The effect of Microvascular Remodeling on Fluid Dynamics in the Pressure Overloaded Right Ventricle.2025 · 1 citations