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April 1, 1988Clinical CardiologyOpen Access

Cardiovascular effects of berberine in patients with severe congestive heart failure

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Why the study?

Does berberine intravenous infusion improve acute cardiovascular hemodynamics in patients with refractory congestive heart failure?

Population

12 patients with refractory congestive heart failure

Comparison

Berberine intravenous infusion at rates of 0.02… vs Baseline (before berberine infusion)

Design

Case_series

Follow-up

1-20 hours after infusion

Authors

BMBenedito Carlos MacielASAntonio L. SecchesLGL Gallo

Discussion

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Overview

May improve acute hemodynamics in refractory HF; case-report evidence and torsades risk leave safety and efficacy open.

Structured PICO

Does berberine intravenous infusion improve acute cardiovascular hemodynamics in patients with refractory congestive heart failure?

P
Population
12 patients with refractory congestive heart failure (refractory to conventional medical therapy with digitalis and diuretics)
I
Intervention
Berberine intravenous infusion at rates of 0.02 and 0.2 mg/kg per min for 30 minutes
C
Comparator
Baseline (before berberine infusion)
O
Outcome
Acute cardiovascular effects (hemodynamic and echocardiographic indices)surrogate

Intravenous berberine improves acute hemodynamics in refractory heart failure but is associated with a concerning risk of torsades de pointes.

Limitations

  • Possible association with ventricular tachycardia requires further elucidation

Cite This Study

Maciel et al. (1988) studied this question.

synapsesocial.com/papers/6a7d09a23575152c8237ccf8https://doi.org/10.1002/clc.4960110411
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of acute alterations in heart rate and systemic arterial pressure on echocardiographic measures of left ventricular perfornmance in normal human subjects.1975 · 130 citations
  2. 2Peripheral Hemodynamic Effects of Intraventricular and Intracoronary Contrast Media in Man1985 · 5 citations
  3. 3Influence of acute changes in preload, afterload, contractile state and heart rate on ejection and isovolumic indices of myocardial contractility in man.1976 · 340 citations
  4. 4Alterations in preload and ejection phase indices of left ventricular performance,.1975 · 95 citations
  5. 5Aggravation and provocation of ventricular arrhythmias by antiarrhythmic drugs.1982 · 633 citations