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April 1, 2001British journal of rheumatology

Correlation of circulating interleukin 16 with proinflammatory cytokines in patients with rheumatoid arthritis

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Population

48 patients fulfilling the 1987 revised American College of Rheumatism criteria for rheumatoid arthritis and…

Design

Case-control

Authors

JKJörg Kaufmann

Discussion

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Overview

IL-16 associations with RA cytokines support its mediator role; leaves open causal and therapeutic implications.

Structured PICO

P
Population
48 patients fulfilling the 1987 revised American College of Rheumatism criteria for rheumatoid arthritis (RA) and 40 healthy controls (total n=88).
C
Comparator
Healthy controls (n=40)
O
Outcome
Correlation between circulating levels of IL-16 and proinflammatory cytokines (IL-1β, TNF-α, IL-6, sIL-6R, sTNFR1, sTNFR2, sIL-2R)surrogate

Circulating IL-16 correlates with multiple proinflammatory cytokines in rheumatoid arthritis, supporting its role as a mediator promoting inflammation.

Cite This Study

Jörg Kaufmann (2001) studied this question.

synapsesocial.com/papers/6a7d09d0d685fe2c2d7752b8https://doi.org/10.1093/rheumatology/40.4.474
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interleukin-10, Interleukin- 16 and Interferon-γ in serum of patients with rheumatoid arthritis and correlation with disease activity2005 · 1 citations
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  3. 3Interleukin-16, produced by synovial fibroblasts, mediates chemoattraction for CD4+ T lymphocytes in rheumatoid arthritis1998 · 116 citations
  4. 4Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients2015 · 54 citations
  5. 5IL-17A, IL-17F and IL-23 in patients with rheumatoid arthritis2024 · 2 citations