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July 1, 2005The Egyptian Journal of Hospital MedicineOpen Access

Interleukin-10, Interleukin- 16 and Interferon-γ in serum of patients with rheumatoid arthritis and correlation with disease activity

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Key result

Serum levels of IL-10, IL-16, and IFN-γ were significantly elevated in patients with rheumatoid arthritis compared to controls (P<0.01) and strongly correlated with ESR and CRP (P<0.001).

Population

30 patients with rheumatoid arthritis and a control group

Design

Case-control

Authors

EREman.M. Abdel RahmanHEHamdia EzzatMMMaha M Abdel Mohsen

Discussion

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Overview

May support RA activity monitoring; leaves open prospective biomarker validation in larger cohorts.

Study Design

Type

Case-Control (n=30)

Structured PICO

P
Population
30 patients with rheumatoid arthritis and a control group evaluated for serum cytokine levels and their correlation with disease activity.
C
Comparator
Control group
O
Outcome
Serum levels of IL-10, IL-16, and IFN-γ and their correlation with disease activity markers (ESR, CRP)surrogate

Main Result

p-value: p=<0.01

Serum levels of IL-10, IL-16, and IFN-γ are elevated in rheumatoid arthritis and correlate strongly with markers of disease activity.

Cite This Study

Rahman et al. (2005) conducted a case-control in Rheumatoid arthritis (n=30). Rheumatoid arthritis vs. Control group was evaluated on Serum levels of IL-10, IL-16, and IFN-γ (p=<0.01). Serum levels of IL-10, IL-16, and IFN-γ were significantly elevated in patients with rheumatoid arthritis compared to controls (P<0.01) and strongly correlated with ESR and CRP (P<0.001).

synapsesocial.com/papers/6a8979ba1acf8e321fbd5950https://doi.org/10.21608/ejhm.2005.18093
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation of circulating interleukin 16 with proinflammatory cytokines in patients with rheumatoid arthritis2001 · 25 citations
  2. 2Rheumatoid arthritis susceptibility and interleukin 10: a study of two ethnically diverse populations2002 · 25 citations
  3. 3Lower level of synovial fluid interferon- in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis2003 · 32 citations
  4. 4The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis1988 · 19,985 citations
  5. 5Elevated interleukin-10 levels in patients with rheumatoid arthritis1995 · 253 citations