What question did this study set out to answer?

Investigate the functional role and molecular mechanism of circular RNA circ_0010074 in cardiac inflammation and fibrosis after myocardial infarction.

June 10, 2025Journal of Radiation Research and Applied SciencesOpen Access

Myocardial circ₀010074 induces cardiac inflammation to facilitate fibrosis by upregulating NLRP1 via sponging miR-214–3p with m6A modification after myocardial infarction

View Full Paper

Ask AI

Bookmark

Authors

XLXiaoyu LiTongji University YYYahan YuDalian Medical University WWWenjuan WangChinese Academy of Medical Sciences & Peking Union Medical College

Discussion

Member takes

Implication

Laboratory study demonstrates that circ_0010074 promotes inflammation and fibrosis via NLRP1 in mouse heart cells, highlighting potential therapeutic targets for myocardial infarction.

Key Points

Investigate the functional role and molecular mechanism of circular RNA circ_0010074 in cardiac inflammation and fibrosis after myocardial infarction.
Established an in vitro myocardial infarction model by exposing primary murine cardiomyocytes to hydrogen peroxide (H2O2).
Identified regulatory interactions among circRNA, miRNA, and mRNA using dual-luciferase reporter gene assays.
Detected N6-methyladenosine (m6A) modification on circ_0010074 using methylated RNA immunoprecipitation (MeRIP).
circ_0010074 was upregulated in myocardial cells following myocardial infarction conditions.
Elevated circ_0010074 induced NLRP1 inflammation and promoted subsequent cardiac fibrosis.
circ_0010074 increased NLRP1 expression by sponging miR-214-3p, an effect intensified by m6A chemical modification.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6a7d0c0a2935e92dbc7752a5 https://doi.org/10.1016/j.jrras.2025.101673

View Full Paper

Ask AI

Bookmark

Implication

Laboratory study demonstrates that circ_0010074 promotes inflammation and fibrosis via NLRP1 in mouse heart cells, highlighting potential therapeutic targets for myocardial infarction.

Myocardial circ₀010074 induces cardiac inflammation to facilitate fibrosis by upregulating NLRP1 via sponging miR-214–3p with m6A modification after myocardial infarction

Discussion

Member takes

Implication

Key Points

Cite This Study

Myocardial circ₀010074 induces cardiac inflammation to facilitate fibrosis by upregulating NLRP1 via sponging miR-214–3p with m6A modification after myocardial infarction

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider