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September 10, 2025HereditasOpen Access

Suppression of circ₀091761 ameliorates acute myocardial infarction-induced endothelial injury through regulation of miR-1278

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Authors

BZBin ZhouHWHaitao WangKZKun Zhang

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Overview

Cellular analysis shows circ_0091761 regulates miR-1278 in endothelial injury due to acute myocardial infarction, suggesting a potential therapeutic target.

Key Points

  • Suppressing circ_0091761 reduces endothelial injury in acute myocardial infarction, improving health outcomes.
  • Inhibition of circ_0091761 led to decreased levels of apoptosis and inflammatory markers such as ICAM1 and VCAM1.
  • Cellular models demonstrated that circ_0091761 interacts negatively with miR-1278, influencing endothelial cell response.
  • Results suggest targeting circ_0091761 may provide novel therapeutic strategies for managing myocardial infarction injuries.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc3754b1d3bfb60f4841https://doi.org/10.1186/s41065-025-00519-z
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