December 1, 1992Journal of Clinical InvestigationOpen Access

Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus.

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Why the study?

Does subcutaneous recombinant human insulin-like growth factor-I improve glucose and lipid metabolism in type 2 diabetics?

Structured PICO

Does subcutaneous recombinant human insulin-like growth factor-I improve glucose and lipid metabolism in type 2 diabetics?

Population

8 type 2 diabetics on a diet

Intervention

Subcutaneous recombinant human insulin-like growth factor-I (rhIGF-I) 2 x 120 micrograms/kg on five treatment days

Comparator

Five control days prior to treatment

Outcome

Fasting and postprandial glucose, insulin, C-peptide, proinsulin, glucagon, triglyceride, insulin-like growth factor-I and -II, and growth hormone levelssurrogate

Short-term administration of subcutaneous rhIGF-I significantly improves fasting and postprandial glucose, insulin, and triglyceride levels in patients with type 2 diabetes.

Discussion

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Implication

rhIGF-I may offer metabolic benefits in type 2 diabetes; hypothesis-generating and should not change practice.

Cite This Study

Zenobi et al. (1992) studied this question.

synapsesocial.com/papers/6a7d0d1697c2c6e465964de4 https://doi.org/10.1172/jci116109

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Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus.

Structured PICO

Discussion

Implication

Cite This Study

Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider