What question did this study set out to answer?

To compare age-, sex-, and body mass index-specific diabetes incidence between young South Asian adults and Pima Indians to evaluate risk disparities at similar body sizes.

March 1, 2021BMJ Open Diabetes Research & CareOpen Access

Incidence of diabetes in South Asian young adults compared to Pima Indians

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Authors

KNK.M. Venkat NarayanNorthwestern University DKDimple KondalPreventive Cardiology SKSayuko KobesNational Institute of Diabetes and Digestive and Kidney Diseases

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Implication

Prospective cohort study reveals divergent diabetes risk profiles across body mass index categories in South Asians and Pima Indians, highlighting impaired insulin secretion in South Asians.

Key Points

To compare age-, sex-, and body mass index-specific diabetes incidence between young South Asian adults and Pima Indians to evaluate risk disparities at similar body sizes.
Analyzed prospective cohort data from the Center for Cardiometabolic Risk Reduction in South Asia Study (n=6,676 in India and Pakistan) and the Pima Indian Study (n=1,852).
Estimated age-, sex-, and body mass index-specific diabetes incidence in individuals aged 20–44 years.
Overall age-standardized incidence was lower in South Asians than Pima Indians (men: 14.2 [95% CI, 12.2–16.2] vs 37.3 [95% CI, 31.8–42.8]; women: 14.8 [95% CI, 13.0–16.5] vs 46.1 [95% CI, 41.2–51.1] cases per 1,000 person-years).
Risk of incident diabetes in adults aged 20–24 years was higher in Pima versus South Asian men (RR 6.04; 95% CI, 3.30–12.0) and women (RR 7.64; 95% CI, 3.73–18.2).
Among individuals with body mass index <25 kg/m², South Asian men had over five times the diabetes risk of Pima Indian men, driven by poorer insulin secretion.

Cite This Study

Narayan et al. (2021) studied this question.

synapsesocial.com/papers/6a7d0f50e9ec6b5ffa6e44a8 https://doi.org/10.1136/bmjdrc-2020-001988

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Implication

Prospective cohort study reveals divergent diabetes risk profiles across body mass index categories in South Asians and Pima Indians, highlighting impaired insulin secretion in South Asians.

Incidence of diabetes in South Asian young adults compared to Pima Indians

Discussion

Member takes

Implication

Key Points

Cite This Study

Incidence of diabetes in South Asian young adults compared to Pima Indians

Discussion

Member takes

Implication

Key Points

Cite This Study

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