Why the study?
Does ambulatory blood pressure monitoring (ABPM) reduce measurement variability and required sample sizes compared to casual office blood pressure (CBP) in pediatric antihypertensive trials?
Population
157 hypertensive children with chronic kidney disease
Comparison
Ambulatory blood pressure monitoring to assess… vs Casual office blood pressure (CBP) measurements
Design
Other
Follow-up
6 months
Authors
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ABPM may enable smaller pediatric antihypertensive trials; extends adult methodological data but leaves outcome impact open.
Does ambulatory blood pressure monitoring (ABPM) reduce measurement variability and required sample sizes compared to casual office blood pressure (CBP) in pediatric antihypertensive trials?
The use of ambulatory blood pressure monitoring in pediatric antihypertensive trials significantly reduces measurement variability, allowing for a 57-75% reduction in required sample sizes compared to casual office blood pressure measurements.
Gimpel et al. (2009) studied this question.
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