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June 11, 2025Cell Death and DiseaseOpen Access

Tumor exosomal circPTBP3 drives gastric cancer peritoneal metastasis via mesothelial-mesenchymal transition

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Why the study?

The peritoneum is the most common site of metastasis in advanced gastric cancer, but the mechanisms underlying gastric cancer peritoneal metastasis remain largely elusive.

Population

GCPM patients and in vivo/in vitro models

Design

In vivo, in vitro, and RNA-seq translational study

Authors

YZYajing ZhouXSXiaochun ShenSHShuo Hu

Discussion

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Overview

Exosome-MMT targeting may merit preclinical exploration in GCPM; leaves open clinical translation pending validation studies.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/6a7d108ec7e6f6a50737cc07https://doi.org/10.1038/s41419-025-07749-z
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Also Consider

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  3. 3PTBP3 Induced Inhibition of Differentiation of Gastric Cancer Cells Through Alternative Splicing of Id12020 · 13 citations