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July 10, 2026Cell Death DiscoveryOpen Access

MFAP2 secreted by TGF-β1-induced cancer-associated fibroblast cells promotes gastric cancer peritoneal metastasis through Src-STAT3-PTK7 axis

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Authors

YTYuen TanShanxi Agricultural UniversitySSShulan SunLiaoning Cancer Hospital & InstituteWWWentao WangDalian University of Technology

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Overview

Randomized trial analyzes MFAP2's role in gastric cancer peritoneal metastasis, suggesting new treatment targets.

Key Points

  • This study investigates the role of MFAP2 in the peritoneal metastasis of gastric cancer.
  • Analyzed peritoneal tissue microenvironment using single-cell transcriptome sequencing from nine patients.
  • Examined the effects of TGF-β1 on mesothelial-mesenchymal transition in peritoneal mesothelial cells.
  • Evaluated the signaling pathways affected by MFAP2 in gastric cancer cells.
  • MFAP2-positive cancer-associated fibroblasts increased with tumor progression and correlated with poor prognosis.
  • TGF-β1 stimulated Smad4 entry into the nucleus, enhancing MFAP2 transcription and mesothelial-mesenchymal transition.
  • MFAP2 activation of the Src-STAT3 pathway increased PTK7 expression, facilitating gastric cancer cell invasion.

Cite This Study

Tan et al. (2026) studied this question.

synapsesocial.com/papers/6a508e5b6eeac72a437a142ehttps://doi.org/10.1038/s41420-026-03243-3
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Also Consider

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  1. 1Stromal fibroblast activation protein alpha promotes gastric cancer progression via epithelial-mesenchymal transition through Wnt/ β-catenin pathway2018 · 81 citations
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  4. 4Senescent Fibroblasts Potentiate Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells<i>via</i>IL-8–mediated Crosstalk2024 · 13 citations
  5. 5Tumor exosomal circPTBP3 drives gastric cancer peritoneal metastasis via mesothelial-mesenchymal transition2025 · 13 citations