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November 12, 2018BMC CancerOpen Access

High stromal FAP expression in gastric cancer patients was associated with a significantly shorter median overall survival compared to low expression (30.2 vs 37.8 months, p<0.01).

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Why the study?

Does stromal fibroblast activation protein alpha promote gastric cancer progression?

Population

60 gastric cancer patients who received radical operation, human gastric cancer cell lines, normal mucosal…

Comparison

Fibroblast activation protein alpha… vs Negative control or low FAP expression.

Design

Preclinical, Pathologists evaluating slides were blinded to the patients'…

Key result

High stromal FAP expression in gastric cancer patients was associated with a significantly shorter median overall survival compared to low expression (30.2 vs 37.8 months, p<0.01).

Authors

JLJiuyang LiuUniversity of Colorado DenverCHChaoqun HuangHubei University of Chinese MedicineCPChun‐Wei PengNational Taiwan University

Discussion

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Member takes

Overview

Does not support FAP testing to guide gastric cancer therapy; hypothesis-generating for stromal-targeted trials.

Study Design

Type

Observational (n=60)

Multicenter

No

Structured PICO

Does stromal fibroblast activation protein alpha promote gastric cancer progression?

P
Population
60 patients with gastric cancer who underwent radical surgery, evaluated for the prognostic impact of stromal fibroblast activation protein alpha (FAP) expression.
E
Exposure
Fibroblast activation protein alpha (FAP) overexpression (HELFFAP cells) and exogenous FAP.
C
Comparator
Negative control (HELFNC cells) or low FAP expression.
O
Outcome
Overall survival (OS), defined as the interval from the date of surgery to GC related death.hard clinical

Main Result

Absolute Event Rate: 30.2% vs 37.8%

p-value: p=<0.01

Stromal FAP promotes gastric cancer progression via EMT through the Wnt/β-catenin pathway and is associated with poorer overall survival, highlighting its potential as a prognostic biomarker.

Cite This Study

Liu et al. (2018) conducted an observational in Gastric cancer (n=60). High stromal FAP expression vs. Low stromal FAP expression was evaluated on Overall survival (p=<0.01). High stromal FAP expression in gastric cancer patients was associated with a significantly shorter median overall survival compared to low expression (30.2 vs 37.8 months, p<0.01).

synapsesocial.com/papers/6a74c8e00b1b00a0ee091b0ehttps://doi.org/10.1186/s12885-018-5035-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FAP Serves as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma2024 · 2 citations
  2. 2MFAP5+ Cancer-associated fibroblasts promote EMT in gastric cancer via lactylation modification leading to CT-detected extramural venous invasion2024
  3. 3MFAP2 secreted by TGF-β1-induced cancer-associated fibroblast cells promotes gastric cancer peritoneal metastasis through Src-STAT3-PTK7 axis2026
  4. 4Fibroblast Activation Protein Alpha (FAP) Expression Is Associated with Disease Recurrence and Poor Response to Tyrosine Kinase Inhibitors in Advanced Clear Cell Renal Cell Carcinoma2025 · 3 citations
  5. 5Fibroblast Activation Protein Alpha (FAP) Expression Is Associated with Disease Recurrence and Poor Response to Tyrosine Kinase Inhibitors in Advanced Clear Cell Renal Cell Carcinoma2025