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Case series reveals high mortality from disseminated Scedosporium prolificans in severely immunocompromised hosts, highlighting the lethal nature of this opportunistic fungal pathogen.
Scedosporium prolificans infection was analyzed in 18 patients from whom the fungus was isolated during the period 1990-1999. Of these 18 patients, 12 had some predisposing factor and either unconfirmed infection or colonization, and 6 patients had confirmed disseminated infection: 4 patients with leukemia died, 1 patient with breast cancer who underwent autologous bone marrow transplantation survived, and 1 patient with advanced acquired immunodeficiency syndrome died, although the fungal infection did not seem to affect his clinical symptoms.
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Idígoras et al. (2001) studied this question.
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