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July 25, 2012International Journal of Molecular MedicineOpen Access

Trimetazidine improves right ventricular function by increasing miR-21 expression

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Why the study?

Does trimetazidine improve right ventricular function and reduce apoptosis in preclinical models of right heart failure?

Population

In vitro cultivated right ventricular myocardial cells and left ventricular myocardial cells, and an in vivo…

Comparison

Trimetazidine vs Control (hypoxia/Su5416 without trimetazidine)

Design

Preclinical

Follow-up

24 hours (in vitro)

Authors

FLFang LiuLYLi YinLZLulu Zhang

Discussion

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Overview

Trimetazidine shows preclinical RV protection; leaves open human translation and miR-21 mechanism confirmation.

Structured PICO

Does trimetazidine improve right ventricular function and reduce apoptosis in preclinical models of right heart failure?

P
Population
In vitro cultivated right ventricular myocardial cells (RVMCs) and left ventricular myocardial cells (LVMCs), and an in vivo right heart failure model (hypoxia + Su5416).
I
Intervention
Trimetazidine (10 µM in vitro; unspecified dose in vivo)
C
Comparator
Control (hypoxia/Su5416 without trimetazidine)
O
Outcome
Right ventricular function (TAPSE), myocardial cell apoptosis, and miR-21 expressionsurrogate

Trimetazidine protects against right ventricular myocardial cell apoptosis and improves right ventricular function in preclinical models, potentially mediated by increased miR-21 expression.

Cite This Study

Liu et al. (2012) studied this question.

synapsesocial.com/papers/6a7d160d166e996abdd5a0d2https://doi.org/10.3892/ijmm.2012.1078
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Also Consider

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  1. 1Trimetazidine inhibits pressure overload-induced cardiac fibrosis through NADPH oxidase–ROS–CTGF pathway2010 · 78 citations
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  4. 4Combination treatment in stable effort angina using trimetazidine and metoprolol. Results of a randomized, double-blind, multicentre study (TRIMPOL II)2001 · 190 citations
  5. 5Contrasting inotropic responses to α<sub>1</sub>-adrenergic receptor stimulation in left versus right ventricular myocardium2006 · 87 citations