Why the study?
Does overexpression of hPMCA4b in arterial smooth muscle cells increase vasomotor responsiveness and blood pressure in mice?
Does overexpression of hPMCA4b in arterial smooth muscle cells increase vasomotor responsiveness and blood pressure in mice?
Overexpression of PMCA4b in arterial smooth muscle cells increases vascular reactivity and blood pressure, likely mediated by negative regulation of nNOS.
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PMCA4b overexpression modulates vascular reactivity in mice; hypothesis-generating for hypertension mechanisms with no clinical implications yet.
Gros et al. (2003) studied this question.
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