March 1, 2007Contrast Media & Molecular Imaging

MR imaging of antigen‐induced arthritis with a new, folate receptor‐targeted contrast agent

View Full Paper

Ask AI

Bookmark

Why the study?

Does the folate receptor-targeted Gd-chelate P866 improve MR imaging enhancement of immune-mediated arthritis in rats compared to non-targeted contrast agents?

Structured PICO

Does the folate receptor-targeted Gd-chelate P866 improve MR imaging enhancement of immune-mediated arthritis in rats compared to non-targeted contrast agents?

Population

15 Sprague-Dawley rats with antigen-induced monoarthritis in the right knee

Intervention

Folate receptor-targeted Gd-chelate P866 (0.02 mmol Gd/kg)

Comparator

Non-FR targeted P866 analog P1001 (0.02 mmol Gd/kg) or Gd-DOTA (0.1 mmol Gd/kg)

Outcome

DeltaSI-data and T(1)-relaxation times of arthritic knees and contralateral normal knees before and up to 2 h and 24 h after injectionsurrogate

The folate receptor-targeted Gd-chelate P866 specifically accumulates in inflamed joints, enabling targeted MR imaging of arthritis in a rat model.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports targeted MR contrast development for arthritis; leaves open clinical translation in inflammatory joint disease.

Cite This Study

Saborowski et al. (2007) studied this question.

synapsesocial.com/papers/6a7d1649469c795fc4278b8e https://doi.org/10.1002/cmmi.128

View Full Paper

Ask AI

Bookmark

MR imaging of antigen‐induced arthritis with a new, folate receptor‐targeted contrast agent

Structured PICO

Discussion

Implication

Cite This Study

MR imaging of antigen‐induced arthritis with a new, folate receptor‐targeted contrast agent

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider