Key result
Longer rheumatoid arthritis duration correlates with worsening left ventricular diastolic dysfunction via reduced E/A ratio.
Why the study?
The predictors of diastolic dysfunction in patients with rheumatoid arthritis required clarification.
Systematic Review (n=2,333)
Yes
68Ga-NODAGA-c(RGDyK) demonstrates potential for PET imaging of inflammation by targeting macrophage accumulation in a preclinical model.
Longer RA duration may signal LV diastolic dysfunction risk; hypothesis-generating in this animal model and requires human validation.
The main objective was to determine the predictors of diastolic dysfunction in rheumatoid arthritis (RA). Articles pertaining to diastolic dysfunction in RA were retrieved from Scopus, EBSCO, PubMed, Web of Science, and Cochrane Library databases. Keywords such as: diastolic, cardiac, left ventricular function, heart failure, rheumatoid arthritis, and cardiac failure were used. Studies, which examined factors, or predictors of diastolic dysfunction in RA, and those with echocardiographic evaluation of diastolic dysfunction, were included. A total of 8 studies met the eligibility criteria. Most studies (6 out of 7 studies) demonstrated a significant inverse relationship between the E (early)/A (late) ratio and disease duration. The pooled analysis using the random effects model revealed a significant but weak inverse relationship between the ratio of the E to A ventricular filling velocities (E/A) ratio and the disease duration (p<0.05, r=-0.385). There was a significant relationship between E/A ratio and disease duration in RA.
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Sakthiswary et al. (2015) conducted a systematic review in Rheumatoid arthritis and left ventricular diastolic dysfunction (n=2,333). Rheumatoid arthritis disease duration vs. Healthy subjects without medical illness or shorter disease duration was evaluated on Correlation between E/A ratio (early to late ventricular filling velocities) and rheumatoid arthritis disease duration (r=-0.385, p=<0.05). Rheumatoid arthritis disease duration showed a significant inverse relationship with the echocardiographic E/A ratio (r=-0.385, p<0.05), predicting left ventricular diastolic dysfunction.
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