Why the study?
Alpha-v-beta-3 integrin is upregulated during angiogenesis soon after AMI, but the determinants of [68Ga]Ga-NODAGA-RGD uptake and its associations with LV function required prospective evaluation.
Does [68Ga]Ga-NODAGA-RGD PET imaging predict left ventricular function improvement in patients after ST-elevation acute myocardial infarction?
Does [68Ga]Ga-NODAGA-RGD PET imaging predict left ventricular function improvement in patients after ST-elevation acute myocardial infarction?
[68Ga]Ga-NODAGA-RGD PET imaging early after STEMI identifies increased αvβ3 integrin expression in the ischemic area at risk, which predicts improvement in global left ventricular function at 6 months.
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Integrin uptake may identify post-AMI patients with greater LV recovery potential; hypothesis-generating for αvβ3-targeted therapies.
Nammas et al. (2023) studied this question.
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